Authors: Benedikt B. Kaufer, Sina Arndt, Sascha Trapp, Nikolaus Osterrieder, Keith W. Jarosinski
DOI: 10.1371/journal.ppat.1002333
Abstract Summary
Researchers mutated the telomerase RNA template in Marek’s disease virus, an oncogenic herpesvirus causing lymphoma in chickens. The mutant virus replicated normally in vitro but completely lost its tumor-forming ability in vivo, while still inducing protective immunity. This novel approach successfully created an effective vaccine that fully protected chickens from lethal viral challenge.
Why Brain? ðŸ§
Mutating viral telomerase RNA template blocks herpesvirus-induced lymphoma in chickens while maintaining vaccine protection, offering a novel strategy for preventing virus-associated cancers.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
