Authors: Jorieke H. Peters, Frank W. Preijers, Rob Woestenenk, Luuk B. Hilbrands, Hans J. P. M. Koenen, Irma Joosten
DOI: 10.1371/journal.pone.0003161
Abstract Summary
Researchers developed a clinical-grade method to isolate regulatory T cells (Tregs) for immunotherapy in autoimmune diseases and transplantation. Using CliniMACS technology with CD127 depletion, they achieved 90% pure Treg populations. The isolated cells could be successfully frozen, expanded while maintaining suppressive function, and enriched for specific antigens—key advances for therapeutic applications.
Why Brain? 🧠
Study establishes clinical-grade protocol for isolating, purifying, and expanding regulatory T cells for immunotherapy in autoimmune diseases and transplantation, achieving 90% purity and potent function.
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