Authors: Zheng Luo, Huimin Liu, Xiaomeng Sun, Rong Guo, Ruibing Cui, Xiangxing Ma, Ming Yan
DOI: 10.1371/journal.pone.0055860
Abstract Summary
Researchers found that blocking DDR2, a receptor involved in liver scarring, reduced liver damage in alcohol-induced disease models. Alcohol triggered DDR2 upregulation, leading to increased collagen deposits and tissue remodeling. Silencing DDR2 decreased harmful cell proliferation and liver injury in rats, suggesting it plays a key role in early alcoholic liver disease and could be a promising therapeutic target.
Why Brain? ðŸ§
Blocking DDR2 protein reduces liver damage in alcoholic liver disease by preventing scar tissue formation and liver cell damage, offering a potential new treatment target for early-stage disease.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
