Monday, December 1, 2025

Increased Expression of Neurotrophin 4 Following Focal Cerebral Ischemia in Adult Rat Brain with Treadmill Exercise

Authors: Jin-Young Chung, Min-Wook Kim, Moon-Suk Bang, Manho Kim

DOI: 10.1371/journal.pone.0052461

Abstract Summary

New research reveals that treadmill exercise boosts NT-4 production in the brain after stroke. In rat models, ischemic injury decreased NT-4 and its receptor trkB, but prior exercise “primed” the brain to produce more NT-4 following injury. This neuroprotective factor, similar to BDNF, may help explain how physical activity enhances recovery after cerebral ischemia.

Why Brain? 🧠

Treadmill exercise boosts neurotrophin-4 levels in rat brains after stroke, suggesting physical activity may prime neuroprotective responses and enhance recovery from ischemic brain injury.


The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.

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