Authors: Fabio Schneider Ribeiro, Isabel Caetano de Abreu da Silva, Vitor Coutinho Carneiro, Fabrรญcio dos Santos Belgrano, Ronaldo Mohana-Borges, Ivone de Andrade Rosa, Marlene Benchimol, Nathalia Rocha Quintino Souza, Rafael Dias Mesquita, Marcos Henrique Ferreira Sorgine, Felipe Gazos-Lopes, Amanda Roberta Revoredo Vicentino, Wenjie Wu, Renata de Moraes Maciel, Mario Alberto Cardoso da Silva-Neto, Marcelo Rosado Fantappiรฉ
DOI: 10.1371/journal.pone.0040192
Abstract Summary
Researchers characterized HMGB1 protein in Aedes aegypti mosquitoes, vectors of dengue and yellow fever. The protein features a unique alanine/glutamine-rich region that regulates DNA binding and bending. Phosphorylation by PKA or PKC completely blocks its DNA activity, revealing novel regulatory mechanisms that could inform mosquito control strategies.
Why Brain? ๐ง
Study identifies unique HMGB1 protein in dengue mosquitoes with novel regulatory features, offering potential new targets for vector control strategies against dengue, chikungunya, and yellow fever.
License: CC BY.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
