Authors: Dahai Zheng, Gino V. Limmon, Lu Yin, Nicola H. N. Leung, Hanry Yu, Vincent T. K. Chow, Jianzhu Chen
DOI: 10.1371/journal.pone.0048451
Abstract Summary
Following severe lung injury, Clara cells—identified by Scgb1a1 expression—serve as key progenitors for regenerating alveolar epithelia. Using transgenic mice, researchers found that after bleomycin or influenza-induced damage, most newly formed type I and II alveolar cells originated from these Clara cells, revealing their critical role in lung repair and recovery.
Why Brain? 🧠
Study identifies Clara cells as key progenitors regenerating damaged lung tissue after severe injury, offering insights into lung repair mechanisms and potential therapeutic targets for acute lung diseases.
License: CC BY.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
