Authors: Takahiro Seno, Masahide Hamaguchi, Eishi Ashihara, Masataka Kohno, Hidetaka Ishino, Aihiro Yamamoto, Masatoshi Kadoya, Kaoru Nakamura, Ken Murakami, Satoaki Matoba, Taira Maekawa, Yutaka Kawahito
DOI: 10.1371/journal.pone.0025541
Abstract Summary
Study reveals 15d-PGJ2, a natural PPARγ agonist, significantly reduces atherosclerotic lesions in mice fed a Western diet. The compound decreased inflammatory markers (MCP-1, TNF-α, MMP-9) and macrophage expression in arterial plaques. This first-ever in vivo demonstration suggests 15d-PGJ2 could offer a promising therapeutic approach for treating atherosclerosis.
Why Brain? 🧠
Natural PPARγ agonist 15d-PGJ2 reduces atherosclerotic plaques in mice by suppressing inflammation and macrophage activity, offering potential as a novel therapeutic approach for atherosclerosis.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
