Monday, December 1, 2025

Human Blood Vessel–Derived Endothelial Progenitors for Endothelialization of Small Diameter Vascular Prosthesis

Authors: Amaresh K. Ranjan, Umesh Kumar, Ashutosh A. Hardikar, Pankaj Poddar, Prabha D. Nair, Anandwardhan A. Hardikar

DOI: 10.1371/journal.pone.0007718

Abstract Summary

Researchers developed a method to coat synthetic bypass grafts with patients’ own endothelial cells to prevent graft failure. They successfully isolated endothelial progenitor cells from human blood vessels, expanded them under xenoprotein-free conditions, and seeded them onto modified ePTFE tubing. This personalized approach could significantly improve outcomes in cardiac bypass surgeries.

Why Brain? 🧠

Researchers successfully isolated and expanded endothelial progenitor cells from human blood vessels to coat synthetic grafts, potentially reducing clotting and improving outcomes in coronary bypass surgery.


The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.

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