Authors: Emmanuelle Uro-Coste, Hervé Cassard, Stéphanie Simon, Séverine Lugan, Jean-Marc Bilheude, Armand Perret-Liaudet, James W. Ironside, Stéphane Haik, Christelle Basset-Leobon, Caroline Lacroux, Katell Peoch’, Nathalie Streichenberger, Jan Langeveld, Mark W. Head, Jacques Grassi, Jean-Jacques Hauw, Francois Schelcher, Marie Bernadette Delisle, Olivier Andréoletti
DOI: 10.1371/journal.ppat.1000029
Abstract Summary
New research challenges the traditional classification of Creutzfeldt-Jakob disease (CJD). While cases are typically categorized by genetic markers and prion protein patterns, scientists found that 30% show mixed protein types. Using advanced biochemical tests, they identified four distinct prion subgroups in both sporadic and iatrogenic CJD that better reflect disease variability than current methods.
Why Brain? 🧠
Study reveals four distinct prion protein subgroups in Creutzfeldt-Jakob disease beyond current classification, offering new understanding of disease strains and potentially improving diagnosis and patient stratification.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
