Authors: Wei-Bing Song, Yuan-Yuan Wang, Fan-Su Meng, Qing-Hua Zhang, Jian-Ying Zeng, Li-Ping Xiao, Xin-Pei Yu, Dan-dan Peng, Lei Su, Bing Xiao, Zhen-Shu Zhang
DOI: 10.1371/journal.pone.0012969
Abstract Summary
Curcumin protects the intestinal barrier in rat models of enteritis by reducing inflammation and oxidative stress. The study found curcumin decreased inflammatory markers (TNF-α, IL-1β) while increasing protective factors (IL-10, SOD). It works by activating MKP-1, inhibiting p38 signaling, and blocking NF-κB translocation—key pathways in intestinal inflammation. These findings suggest curcumin’s potential as a therapeutic agent for intestinal barrier dysfunction and related diseases.
Why Brain? 🧠
Curcumin protects intestinal barrier function in rat enteritis by activating anti-inflammatory pathways and reducing oxidative stress, offering potential as a therapeutic agent for intestinal diseases.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
