Authors: Patrick Linsel-Nitschke, Anika Götz, Jeanette Erdmann, Ingrid Braenne, Peter Braund, Christian Hengstenberg, Klaus Stark, Marcus Fischer, Stefan Schreiber, Nour Eddine El Mokhtari, Arne Schaefer, Jürgen Schrezenmeier, Diana Rubin, Anke Hinney, Thomas Reinehr, Christian Roth, Jan Ortlepp, Peter Hanrath, Alistair S. Hall, Massimo Mangino, Wolfgang Lieb, Claudia Lamina, Iris M. Heid, Angela Doering, Christian Gieger, Annette Peters, Thomas Meitinger, H.-Erich Wichmann, Inke R. König, Andreas Ziegler, Florian Kronenberg, Nilesh J. Samani, Heribert Schunkert
DOI: 10.1371/journal.pone.0002986
Abstract Summary
A common genetic variant in the LDLR gene significantly impacts cholesterol levels and heart disease risk. Researchers found that carriers of the minor T allele (rs2228671) had notably lower LDL cholesterol—0.19 mmol/L per copy—and an 18% reduced risk of coronary artery disease. This protective effect operates entirely through cholesterol reduction, establishing a clear genetic link between LDLR variation and cardiovascular health.
Why Brain? 🧠
Common genetic variant in LDL-receptor gene lowers cholesterol lifelong and reduces coronary artery disease risk by 18%, proving causal link between LDL-cholesterol levels and heart disease.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
