Authors: Jin Yu, Ngan F. Huang, Kitchener D. Wilson, Jeffrey B. Velotta, Mei Huang, Zongjin Li, Andrew Lee, Robert C. Robbins, John P. Cooke, Joseph C. Wu
DOI: 10.1371/journal.pone.0007040
Abstract Summary
Low-dose nicotine surprisingly enhances survival and therapeutic effects of transplanted human embryonic stem cell-derived endothelial cells in mouse hearts after injury. The treatment activated protective signaling pathways, increased capillary formation, and improved cell survival at six weeks—suggesting nicotine’s complex role beyond its harmful effects in smoking.
Why Brain? đź§
Low-dose nicotine unexpectedly improves survival and blood vessel formation of transplanted stem cell-derived endothelial cells in heart attack models, suggesting new therapeutic strategies.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
