Authors: Jing Yang, Chin Yee Chan, Bo Jiang, Xueyuan Yu, Guo-Zhang Zhu, Yiping Chen, John Barnard, Wenyan Mei
DOI: 10.1371/journal.pgen.1000363
Abstract Summary
Researchers discovered that hnRNP I protein acts as a crucial brake on Notch signaling in the intestine, maintaining healthy gut balance. Using zebrafish mutants lacking functional hnRNP I, they observed excessive cell proliferation, increased cell death, and defective goblet cell formation. The protein works by destabilizing Notch’s active form—a mechanism conserved from fish to humans—offering new insights into intestinal stem cell regulation.
Why Brain? 🧠
hnRNP I protein inhibits Notch signaling and maintains intestinal balance by controlling stem cell growth and cell differentiation, offering insights into gut health mechanisms conserved from zebrafish to humans.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
