Ex Vivo Generation of Human Alloantigen-Specific Regulatory T Cells from CD4 pos CD25 high T Cells for Immunotherapy

Authors: Jorieke H. Peters, Luuk B. Hilbrands, Hans J. P. M. Koenen, Irma Joosten

DOI: 10.1371/journal.pone.0002233

Abstract Summary

Researchers developed an efficient method to generate antigen-specific regulatory T cells (Tregs) for immunotherapy in just two stimulation cycles. Using mismatched donor cells and growth factors, they achieved high specificity and cell numbers. This ex vivo expansion protocol could enhance transplant tolerance while minimizing broad immune suppression, particularly benefiting HLA-mismatched organ recipients.

Why Brain? 🧠

Researchers developed a method to create antigen-specific regulatory T cells that could prevent transplant rejection while preserving normal immunity, offering a targeted immunotherapy approach for organ recipients.

The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.