Authors: Yosef Refaeli, Ryan M Young, Brian C Turner, Jennifer Duda, Kenneth A Field, J. Michael Bishop
DOI: 10.1371/journal.pbio.0060152
Abstract Summary
Mouse models reveal that B cell receptor (BCR) signaling directly drives lymphoma development. Constitutive BCR activity led to chronic lymphocytic leukemia-like tumors, while antigen-stimulated BCR produced Burkitt lymphoma-like cancers dependent on continued antigen exposure. Disrupting BCR signaling killed tumor cells, and immunosuppressants inhibited growth—providing proof that antigenic stimulation fuels lymphomagenesis.
Why Brain? ðŸ§
Mouse models show B cell receptor signaling cooperates with MYC overexpression to cause lymphomas resembling human B-CLL and Burkitt lymphoma, suggesting antigen stimulation drives cancer development.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
