Monday, December 1, 2025

Machine Perfusion versus Cold Storage of Kidneys Derived from Donation after Cardiac Death: A Meta-Analysis

Authors: Ronghai Deng, Guangxiang Gu, Dongping Wang, Qiang Tai, Linwei Wu, Weiqiang Ju, Xiaofeng Zhu, Zhiyong Guo, Xiaoshun He

DOI: 10.1371/journal.pone.0056368

Abstract Summary

Machine perfusion preservation of kidneys from cardiac death donors reduces delayed graft function by 44% compared to static cold storage, according to a meta-analysis of four randomized trials. However, both methods showed similar outcomes for primary non-function and one-year survival rates.

Why Brain? 🧠

Machine perfusion reduces delayed graft function in cardiac death donor kidneys compared to cold storage, though long-term outcomes remain similar, offering a strategy to improve marginal organ use.


The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.

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