Authors: Noah Saederup, Astrid E. Cardona, Kelsey Croft, Makiko Mizutani, Anne C. Cotleur, Chia-Lin Tsou, Richard M. Ransohoff, Israel F. Charo
DOI: 10.1371/journal.pone.0013693
Abstract Summary
Scientists developed fluorescent mice to track immune cell movement in multiple sclerosis models. They discovered that CCR2 protein is essential for inflammatory monocytes to enter the central nervous system, and surprisingly, neutrophils—not other monocyte types—compensate when this pathway fails. This new model enables researchers to distinguish invading immune cells from brain-resident cells for the first time.
Why Brain? 🧠
Novel mouse model reveals CCR2 chemokine receptor is essential for inflammatory monocyte entry into the brain during autoimmune disease, enabling distinction of infiltrating immune cells from resident microglia.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
