Authors: Theodora Szasz, Robert Patrick Davis, Hannah S. Garver, Robert J. Burnett, Gregory D. Fink, Stephanie W. Watts
DOI: 10.1371/journal.pone.0056046
Abstract Summary
Febuxostat, a potent xanthine oxidase inhibitor, failed to significantly reduce blood pressure in DOCA-salt hypertensive rats despite effectively blocking the enzyme. While long-term treatment showed minimal vascular improvements, the study concludes that xanthine oxidase inhibition alone is insufficient to combat hypertension in this model.
Why Brain? ðŸ§
Febuxostat, a potent xanthine oxidase inhibitor, failed to significantly reduce blood pressure in hypertensive rats, suggesting XO inhibition alone may be insufficient for treating salt-sensitive hypertension.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
