Syncytiotrophoblast Microvesicles Released from Pre-Eclampsia Placentae Exhibit Increased Tissue Factor Activity

Authors: Chris Gardiner, Dionne S. Tannetta, Carol A. Simms, Paul Harrison, Christopher W. G. Redman, Ian L. Sargent

DOI: 10.1371/journal.pone.0026313

Abstract Summary

Placental microvesicles from pre-eclamptic pregnancies trigger faster blood clotting than those from healthy pregnancies. These particles, shed into maternal circulation, activate thrombin generation via tissue factor—a mechanism more pronounced in pre-eclampsia. Since pre-eclampsia releases more microvesicles, this discovery helps explain the dangerous clotting complications seen in this condition.

Why Brain? 🧠

Pre-eclampsia placentae release microvesicles with heightened clotting activity, explaining increased blood coagulation in this pregnancy complication and offering insights into its mechanism.

The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.