Monday, December 1, 2025

A Novel Endogenous Inhibitor of the Secreted Streptococcal NAD-Glycohydrolase

Authors: Michael A Meehl, Jerome S Pinkner, Patricia J Anderson, Scott J Hultgren, Michael G Caparon

DOI: 10.1371/journal.ppat.0010035

Abstract Summary

Researchers discovered IFS, a bacterial protein that protects Streptococcus pyogenes from its own toxic enzyme SPN. This small inhibitor binds SPN in a 1:1 ratio, blocking its cell-damaging activity and proving essential for bacterial survival. The finding reveals how bacteria safely produce potent toxins and enabled safer toxin production for research purposes.

Why Brain? 🧠

Researchers discovered IFS, a bacterial protein that protects Streptococcus pyogenes from its own toxic enzyme SPN, revealing how bacteria avoid self-harm while causing disease in humans.


The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.

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