Authors: Ting-Ting Hong, James W. Smyth, Danchen Gao, Kevin Y. Chu, Jacob M. Vogan, Tina S. Fong, Brian C. Jensen, Henry M. Colecraft, Robin M. Shaw
DOI: 10.1371/journal.pbio.1000312
Abstract Summary
Researchers discovered that BIN1, a scaffolding protein in heart cell membrane invaginations, anchors microtubules that transport calcium channels directly to T-tubules—structures critical for cardiac contraction. This finding reveals a key mechanism for how heart cells organize their calcium signaling machinery, with potential implications for understanding heart disease.
Why Brain? ðŸ§
BIN1 protein guides calcium channels to heart cell membranes via microtubule transport, revealing a key mechanism for proper cardiac electrical signaling and potential heart disease targets.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
