Authors: Tarek M. A. Elsaba, Luisa Martinez-Pomares, Adrian R. Robins, Simon Crook, Rashmi Seth, Darryl Jackson, Amy McCart, Andrew R. Silver, Ian P. M. Tomlinson, Mohammad Ilyas
DOI: 10.1371/journal.pone.0010714
Abstract Summary
CD133, a controversial colorectal cancer stem cell marker, doesn’t affect tumor cell proliferation but enhances resistance to drug-induced cell death, increases cell motility, and improves colony formation. Notably, CD133-negative cells can revert to CD133-positive status, demonstrating plasticity in expression and challenging traditional stem cell hierarchies.
Why Brain? đź§
CD133 protein in colorectal cancer cells enhances colony formation, cell movement, and resistance to cell death, but doesn’t affect growth rate. CD133-negative cells can regain CD133 expression over time.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
