Authors: Marina A. Aleksinskaya, Ernst E. H. van Faassen, Jelly Nelissen, Ben J. A. Janssen, Jo G. R. De Mey, Roeland Hanemaaijer, Ton Rabelink, Anton Jan van Zonneveld
DOI: 10.1371/journal.pone.0057761
Abstract Summary
Researchers directly measured nitric oxide (NO) in bone marrow for the first time using advanced spectroscopy techniques. They found that NO levels correlate with MMP9, a key enzyme for stem cell mobilization. In hypertensive rats, impaired NO signaling may explain poor stem cell release from bone marrow—a defect potentially treatable with drugs.
Why Brain? 🧠
First direct detection of nitric oxide in bone marrow reveals impaired stem cell mobilization in hypertension, potentially correctable with drugs, offering new therapeutic targets for cardiovascular disease.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
