Authors: Julien Vermot, Arian S. Forouhar, Michael Liebling, David Wu, Diane Plummer, Morteza Gharib, Scott E. Fraser
DOI: 10.1371/journal.pbio.1000246
Abstract Summary
Local blood flow direction in zebrafish embryonic hearts plays a critical role in proper heart valve development. This finding highlights how mechanical forces from circulation guide cardiac morphogenesis, offering insights into congenital heart defects and potential therapeutic targets.
Why Brain? đź§
Zebrafish study reveals blood flow direction controls heart valve development through klf2a gene, advancing understanding of congenital valve defects and potential therapeutic targets.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
