Stereoselective Regulations of P-Glycoprotein by Ginsenoside Rh2 Epimers and the Potential Mechanisms From the View of Pharmacokinetics

Authors: Jingwei Zhang, Fang Zhou, Fang Niu, Meng Lu, Xiaolan Wu, Jianguo Sun, Guangji Wang

DOI: 10.1371/journal.pone.0035768

Abstract Summary

Researchers discovered that ginsenoside Rh2 stereoisomers regulate P-glycoprotein differently based on their 3D structure. The 20(S) form enhanced drug absorption dose-dependently, while 20(R) showed diminishing effects at higher doses. Both compounds and their metabolites exhibited stereoselective P-gp regulation, with in vivo effects resulting from combined actions of parent compounds and metabolites.

Why Brain? 🧠

Ginsenoside Rh2 epimers show stereoselective effects on P-glycoprotein drug transporter. The study reveals that both parent compounds and metabolites regulate drug absorption differently based on their 3D structure.

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