Authors: Padma Singh, Manglesh Kumar Singh, Dilip Chaudhary, Vinita Chauhan, Pranay Bharadwaj, Apurva Pandey, Nisha Upadhyay, Ram Kumar Dhaked
DOI: 10.1371/journal.pone.0047110
Abstract Summary
Researchers identified a promising small-molecule inhibitor against botulinum neurotoxin type A, the most toxic substance known. Using computational screening of chemical libraries, they discovered NSC 84087, which potently blocks the toxin’s protease activity with nanomolar potency. Crucially, this non-toxic compound protected animals both before and after toxin exposure, offering hope for the first pharmacological treatment for botulism.
Why Brain? 🧠
Novel quinolinol compound NSC 84087 effectively blocks botulinum toxin A in mice before and after exposure, offering first potential treatment for botulism poisoning where current therapies fail.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
