Authors: Hong-Yuan Chu, Qinhua Gu, Guo-Zhang Jin, Guo-Yuan Hu, Xuechu Zhen
DOI: 10.1371/journal.pone.0013118
Abstract Summary
SKF83959, a drug used for Parkinson’s disease, protects neurons through a newly discovered mechanism. Researchers found it activates HCN channels in hippocampal neurons, independent of dopamine receptors—contrary to previous assumptions. This activation increases Ih current, causing neuronal depolarization while reducing excitability. These findings reveal a novel neuroprotective pathway that may enhance the drug’s therapeutic benefits.
Why Brain? đź§
SKF83959, a Parkinson’s drug, protects neurons by enhancing Ih currents in hippocampal cells independent of dopamine receptors, revealing a novel neuroprotective mechanism beyond its known anti-parkinsonian effects.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
