Authors: Giselle Chamberlain, Karina Wright, Antal Rot, Brian Ashton, Jim Middleton
DOI: 10.1371/journal.pone.0002934
Abstract Summary
Researchers identified key chemokine receptors on mesenchymal stem cells (MSCs) that guide their migration to injury sites. Both mouse and human bone marrow MSCs expressed similar receptors—CCR6, CCR9, CXCR3, and CXCR6—which were functionally active in directing cell movement. This discovery explains how MSCs naturally home to damaged tissues and supports their use in regenerative medicine and tissue engineering applications.
Why Brain? 🧠
Study reveals mouse stem cells have limited but functional chemokine receptors similar to humans, enabling targeted migration to injury sites – key for developing stem cell therapies.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
