Authors: Xiaoning Chen, Kara J. Margolis, Michael D. Gershon, Gary J. Schwartz, Ji Y. Sze
DOI: 10.1371/journal.pone.0032511
Abstract Summary
SERT-deficient mice reveal a paradox: despite eating less and having high leptin levels, they develop obesity, diabetes, and fatty liver due to insulin resistance. The study shows serotonin transport separately controls appetite and metabolism, with implications for designing better antidepressants.
Why Brain? ðŸ§
SERT-deficient mice develop insulin resistance and fatty liver despite eating less food, revealing that serotonin transporter affects metabolism independently of appetite, with implications for SSRI design.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
