Sunday, October 19, 2025

The Flavoring Agent Dihydrocoumarin Reverses Epigenetic Silencing and Inhibits Sirtuin Deacetylases

Authors: Andrew J Olaharski, Jasper Rine, Brett L Marshall, Joshua Babiarz, Luoping Zhang, Eric Verdin, Martyn T Smith

DOI: 10.1371/journal.pgen.0010077

Abstract Summary

Dihydrocoumarin (DHC), a compound from sweet clover commonly used in foods and cosmetics, inhibits sirtuin enzymes linked to aging processes. Research shows DHC disrupts cellular functions in both yeast and human cells, increasing protein acetylation and triggering cell death. This suggests everyday exposure to chemicals that may accelerate aging.

Why Brain? 🧠

Dihydrocoumarin, a common food and cosmetic flavoring agent, inhibits sirtuin enzymes linked to aging and triggers cell death. This discovery reveals potential health risks from everyday exposure.


The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.

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