Sunday, October 19, 2025

Apoptosis at Inflection Point in Liquid Culture of Budding Yeasts

Authors: Toshiyuki Hagiwara, Takashi Ushimaru, Kei-ichi Tainaka, Hironori Kurachi, Jin Yoshimura

DOI: 10.1371/journal.pone.0019224

Abstract Summary

Researchers discovered that aging yeast cells undergo programmed cell death (apoptosis) after just 6 cell divisions in liquid culture – much earlier than the 20-30 divisions seen on solid media. By tracking “bud scars” that mark each division, they found older cells mysteriously disappeared, with microscopy revealing cell breakage.

Why Brain? đź§ 

Study reveals budding yeast cells undergo programmed cell death (apoptosis) after 6+ divisions in liquid culture, contradicting expected cell counts and suggesting aging limits.

The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.

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