Sunday, October 19, 2025

Myogenic Potential of Whole Bone Marrow Mesenchymal Stem Cells In Vitro and In Vivo for Usage in Urinary Incontinence

Authors: Monica Gunetti, Simone Tomasi, Alessandro Giammò, Marina Boido, Deborah Rustichelli, Katia Mareschi, Edoardo Errichiello, Maurizio Parola, Ivana Ferrero, Franca Fagioli, Alessandro Vercelli, Roberto Carone

DOI: 10.1371/journal.pone.0045538

Abstract Summary

Researchers tested mesenchymal stem cells (MSCs) as a potential treatment for urinary incontinence, which affects 30% of women and 15% of men over 60. When transplanted near the urethral sphincter, MSCs survived long-term, migrated into muscle tissue, and showed no safety concerns or tumor formation.

Why Brain? 🧠

Bone marrow stem cells show promise for treating urinary incontinence by safely surviving in pelvic muscles without immunosuppression, migrating to muscle fibers and nerve junctions.

The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.

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