Authors: Fred Stephen Sarfo, Richard O. Phillips, Brian Rangers, Engy A. Mahrous, Richard E. Lee, Edward Tarelli, Kingsley B. Asiedu, Pamela L. Small, Mark H. Wansbrough-Jones
DOI: 10.1371/journal.pntd.0000577
Abstract Summary
Researchers successfully detected mycolactone A/B toxin in human tissue samples from all 10 patients with Buruli ulcer, a neglected tropical disease affecting children in West Africa. The toxin showed cytotoxic and inflammatory effects in lab tests, confirming its role in tissue destruction. This breakthrough could improve antibiotic treatment strategies.
Why Brain? 🧠
First direct detection of mycolactone toxin in human Buruli ulcer tissue confirms its role in disease pathogenesis and suggests potential for improved diagnosis and treatment monitoring.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
