Authors: Shinya Dohgu, Jan S. Ryerse, Sandra M. Robinson, William A. Banks
DOI: 10.1371/journal.pone.0039565
Abstract Summary
HIV-1 uses the mannose-6 phosphate receptor (M6PR) to cross the blood-brain barrier as free virus, researchers discovered. Brain perfusion and ultrastructural studies confirmed HIV-1 crosses via transcytosis in all brain regions. Transport was blocked by mannose compounds and required calcium, suggesting therapeutic targets.
Why Brain? ðŸ§
HIV-1 uses the mannose-6-phosphate receptor to cross the blood-brain barrier as free virus, providing new insights into how the virus enters the brain and potentially offering targets for prevention.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
