Authors: Lu Zhu, Lingdi Wang, Xiao Wang, Xiaolin Luo, Ling Yang, Rui Zhang, Hongkun Yin, Dong Xie, Yi Pan, Yan Chen
DOI: 10.1371/journal.pone.0017415
Abstract Summary
New research reveals that Smad7, a protein that regulates TGF-β signaling, plays a crucial protective role in liver health. Mice lacking Smad7 in liver cells developed spontaneous liver dysfunction and showed dramatically worsened alcohol-induced liver damage, including increased fat accumulation and inflammation.
Why Brain? 🧠
Study reveals Smad7 protein protects liver function – mice lacking it develop spontaneous liver damage and worse alcohol-induced injury, suggesting new therapeutic targets for liver disease.
The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.
