Dedifferentiation of Human Primary Thyrocytes into Multilineage Progenitor Cells without Gene Introduction

Authors: Keiji Suzuki, Norisato Mitsutake, Vladimir Saenko, Masatoshi Suzuki, Michiko Matsuse, Akira Ohtsuru, Atsushi Kumagai, Tatsuya Uga, Hiroshi Yano, Yuji Nagayama, Shunichi Yamashita

DOI: 10.1371/journal.pone.0019354

Abstract Summary

Researchers developed a breakthrough method to transform normal thyroid cells into versatile stem-like progenitor cells. Using a specialized culture system, they successfully dedifferentiated thyroid follicular cells, which then regained the ability to become various cell types including neurons and fat cells.

Why Brain? 🧠

Researchers developed a method to convert mature thyroid cells into multipotent stem-like cells without genetic modification, using only a specialized culture medium called SAGM.

The image is AI-generated for illustrative purposes only. Courtesy of Midjourney.